Formulation and evaluation of hard capsule containing extract of Calyx hibisci

Abstract

 Hibiscus sabdariffa L. calyx is a medicinal herb with many pharmacological effects and is widely used for lowering uricemia. However, H. sabdariffa calyx is only commonly used in traditional formulations, and research on modern formulations from H. sabdariffa calyx is still very limited. The study aimed to formulate and evaluate the capsules containing the extract of H. sabdariffa calyx. H. sabdariffa calyx was extracted by using percolation. Extraction method was investigated by using distilled water and 96% ethanol. The hard capsule was formulated by using absorbent (aerosil/CaCO3), diluent (acivel PH 102), disintegrant (sodium croscarmellose), and glidant (talc) and wet granulation method. The amount of anthocyanin in capsule was determined by UV spectrometry. H. sabdariffa calyx was extracted using distilled water. The capsule contains H.sabdariffa calyx extract (63.29%), aerosil/CaCO3 (12.66%), avicel PH 102 (22.15%),sodium croscarmellose (1.27%) and talc (0.63%). The anthocyanin content in the capsulewas 0.714%. The capsule was successfully prepared and evaluated.