Toxicity assessment and anti-inflammatory effects of male papaya flower extract
DOI:
https://doi.org/10.56097/binhduonguniversityjournalofscienceandtechnology.v7i2.250Keywords:
Độc tính cấp; Đu đủ dực; Giảm ho; Hoa cây Đu đủ đực; Ức chế ho.Abstract
Male papaya flower is a medicinal herb used in traditional medicine to treat
cough symptoms. Male papaya flower was extracted using the maceration method (96%
ethanol solvent). The safety of male Papaya flower extract was tested on male mice who
received the highest dose drawn through a needle, with mortality and toxicity monitored
for 72 hours. The extract's cough-reducing effect was tested on an acute cough model in a
1 liter closed bottle containing 25% amoniac. Mice were given male papaya flower extract
at doses of 3.6 g/kg and 1.8 g/kg for three days, with Neo-codion® 1 tablet/kg serving as a
positive control. On the third day, one hour after administration, induce cough and assess
the number of latent cough periods, cough counts, and cough inhibition ability. The result
show that male papaya flower extract was safely administered to mice at a Dmax dose of
18 g/kg. In the acute cough model, doses of 3.6 g/kg and 1.8 g/kg both reduced the number
of coughs by a statistically significant amount compared to the control group.
